Article Correctness Is Author's Responsibility: Temple researchers identify cardiac protein that causes different types of heart failure

(Temple University Health System) Heart damage typically progresses, owing to oxidative stress and toxic lipids that alter heart cell energetics and the heart's ability to function normally.Oxidative stress occurs when harmful oxygen-containing molecules outnumber helpful antioxidants, leading to damaging reactions with proteins, DNA, and other cell components. Temple researchers show that in the heart, Kruppel-like factor-5, fuels both the generation of oxidizing molecules and the accumulation of toxic lipids known as ceramides in the heart, exacerbating heart dysfunction.