Article Correctness Is Author's Responsibility: New study gives clue to the cause, and possible treatment of Parkinson’s Disease

(Niigata University) This study will benefit scientists and experts in brain research where new discoveries of biomarkers are needed to form part of routine clinical practice protocols. The study relies on zebrafish Parkinson's Disease model, showing how cytosolic dsDNA of mitochondrial origin can accumulate in brains cells thereby contributing to PD pathogenesis. The evidence presented in this manuscript illustrates that upregulation of DNAse II can counteract the dsDNA deposits, thereby blocking the IFI16-mediated cascade of proinflammatory responses.